Serkan Kır

Dr. Serkan Kır received his PhD degree from the University of Texas Southwestern Medical Center at Dallas in 2011. He completed a Post-doctoral fellowship at Dana-Farber Cancer Institute/Harvard Medical School with Prof. Bruce Spiegelman and joined Koç University in 2017 as an Assistant Professor in the Department of Molecular Biology and Genetics. Dr. Kir’s research interests include adverse effects of tumours on host metabolism. His ongoing studies address tumour-driven hypermetabolism and the loss of adipose and skeletal muscle tissues. Dr. Kir identified PTHrP, a tumour-derived hormonal factor, as an inducer of energy wasting and adipose tissue atrophy. His laboratory currently investigates a missing link in tumour signalling to skeletal muscle that triggers the loss muscle mass and function. For more information please visit his laboratory website.

Selected Publications

Parathyroid hormone directs bone marrow mesenchymal cell fate. Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Baron R, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Belizikian JP, Martin JT, Dempster DW, Rosen CJ, Lanske B. Cell Metab (2017) 25: 661-672.

PTH/PTHrP receptor mediates cachexia in models of kidney failure and cancer. Kir S, Komaba H, Garcia AP, Konstantinos E, Suh H, Lanske B, Hodin RA, Spiegelman BM. Cell Metab (2016) 23: 315-323.

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, Spiegelman BM. Nature (2014) 513: 100-104.

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ. Science (2011) 331: 1621-24.