Özlem Yalçın

Dr. Özlem Yalçın received her PhD from the Department of Physiology, Akdeniz University. She worked as a post-doctoral fellowship at University of California San Diego with Prof. Paul Johnson, Prof. Pedro Cabrales and she is currently an Assistant Professor in the Koç University School of Medicine, Department of Physiology. Her research interests include blood banking, microcirculation, coagulation disorders, microfluidics and medical applications, hemorheology, hemodynamics and blood-related proteomics. Ongoing projects in her laboratory are: 1. The role of shear forces and effective factors in the regulation of red blood cell deformability. 2. Development of a portable thromboelastometry device for evaluating the coagulation pathway. 3. Dynamics of adenosine triphosphate release in erythrocytes. 4. Regulation of blood flow in the microcirculation. 5. Development of portable automatic blood group system with disposable cartridges. 6. Detection of diagnostic and prognostic markers in patients with immune thrombocytopenic purpura (ITP). 7. Evaluation by rotational thromboelastography of the hypercoagulable state among allogeneic stem cell donors undergoing apheresis before transplantation. 8. Comparing the effects of oral mucosa-derived heterotopic fibroblasts and dermal fibroblasts on cutaneous wound healing. 9. The effects of hyperbaric oxygen therapy on the blood fluidity in patients with various disorders. For more information please visit the research lab page (http://home.ku.edu.tr/~ozlemyalcin/index.html).

 

Recent Publications

(SCI) Renoux C, Joly P, Faes C, Mury P, Eglenen B, Turkay M, Yavas G, Yalcin O, Bertrand Y, Garnier N, Cuzzubbo D, Gauthier A, Romana M, Möeckesch B, Cannas G, Antoine-Jonville S, Pialoux V, Connes P, “Homozygous alpha-thalassemia reduces oxydative and nitrosative stress in children with sickle cell anemia”. Journal of Pediatrics, December 9, 2017 (Epub ahead of print).

(SCI) Goktas S, Yalcin O, Ermek E, Piskin S, Capraz CT, Cakmak YO, Pekkan K, “Haemodynamic Recovery Properties of the Torsioned Testicular Artery Lumen”. Scientific Reports, 2017 Nov 14;7(1):15570.

(SCI) Dufu K, Yalcin O, Ao-ieong E, Hutchaleelala A, Xu Q, Li Z, Vlahakis N, Oksenberg D, Lehrer-Graiwer J, Cabrales P, “GBT1118, a potent allosteric modifier of hemoglobin oxygen affinity increases tolerance to severe hypoxia in mice”.Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H381-H391.

(SCI) Jani VP, Yalcin O, Williams A, Popovsky MA, Cabrales P, “Red blood cell biomechanical storage lesions during cold storage”. Clin Hemorheol Microcirc. 2017;67(1):45-57.

(SCI) Ertan NZ, Bozfakioglu S, Ugurel E, Sinan M, Yalcin O, “Alterations of erythrocyte rheology and cellular susceptibility in severe chronic kidney disease: effects of peritoneal dialysis and oxidative stress”. Plos One,2017 Feb 3;12 (2):e0171371.

(SCI) Ugurel E, Kucuksumer Z, Eglenen B, Yalcin O, “Blood storage alters mechanical stress responses of erythrocytes”. Clinical Hemorheology and Microcirculation 66 (2017) 143–155.