Dr. Zeybel received his medical degree from Hacettepe University. Following the completion of internal medicine residency, he has been trained as gastroenterologist and in the last year of his training he started to work on epigenetic regulation of hepatic stellate cells and liver fibrosis at Newcastle University. Dr Zeybel continued his medical research career at Newcastle University by studying a Master of Research and Ph.D. on liver disease. He worked as an European Association for the Study of the Liver, Sheila Sherlock Physician Scientist Fellow on epigenetics and liver disease. His research topics include non-alcoholic fatty liver disease, epigenetic targets and treatment in chronic liver disease and hepatocellular carcinoma. He has received fundings from TUBİTAK, European Commission, Marie Curie Fellowship (2015-2017), Science Academy and EASL Physician Scientist Sheila Sherlock Fellowship.

 

Selected Publications

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Moran Salvador E, Sharkey V, Tsukamoto H, Chu DCK, Singh US, Ponzoni M, Perri P, Di Paolo D, Mendivil EJ, Mann J, Mann DA. Mol Ther. 2017 Jan 4;25(1):218-231.

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease. Hardy T, Zeybel M, Day CP, Dipper C, Masson S, McPherson S, Henderson E, Tiniakos D, White S, French J, Mann DA, Anstee QM, Mann J.Gut. 2017 Jul;66(7):1321-1328.

Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. Zeybel M, Hardy T, Robinson SM, Fox C, Anstee QM, Ness T, Masson S, Mathers JC, French J, White S, Mann J. Clinical Epigenetics. 2015,14;7(1):25.

Epigenetic modifications as new targets for liver disease therapies. Zeybel M, Mann DA, Mann J. Journal of Hepatology. 2013,59(6):1349-53.

Multigenerational epigenetic adaptation of the hepatic wound-healing response. Zeybel M, Hardy T, Wong YK, Mathers JC, Fox CR, Gackowska A, Oakley F, Burt AD, Wilson CL, Anstee QM, Barter MJ, Masson S, Elsharkawy AM, Mann DA, Mann J. Nature Medicine. 2012 Sep;18(9):1369-77.