Gözde Korkmaz

Gözde Korkmaz obtained her Bachelor’s degree in Molecular Biology and Genetics department from Istanbul Technical University. She received her PhD degree from Sabancı University Department of Biological Sciences and Bioengineering in 2012. She conducted her post-doctoral studies at Reuven Agami’s laboratory at the Netherlands Cancer Institute. In 2020, she joined Koç University, School of Medicine as an assistant professor and started her own lab. She is a recipient of TÜBİTAK 2232 International Fellowship for Outstanding Researchers Program.

 

Our research revolves around the transcriptional regulation and epigenetics, and their role in cancer development and drug resistance. Mainly, techniques based on CRISPR (such as genome-scale CRISPR-Cas9 screens) are combined with next-generation sequencing to identify new therapeutic targets in cancer.

 

Selected publications:

 

  1. Korkmaz G*, Lopes R*, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R. Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Nat Biotechnol. 2016 Feb;34(2):192-8. doi:10.1038/nbt.3450.
  2. Lopes R*, Korkmaz G#*, Agami R#. Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers. Nat Rev Mol Cell Biol. 2016 Sep;17(9):597-604. doi: 10.1038/nrm.2016.79.
  3. Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D. miR-376b controls. starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy. 2012 Feb 1;8(2):165-76. doi: 10.4161/auto.8.2.18351.