Buse Cevatemre

Dr. Buse Cevatemre holds a bachelor’s degree from Celal Bayar University and M.Sc. and Ph.D. degrees from Uludağ University. During her higher education she was involved as an investigator in 13 research projects on anti-cancer drug development and cell death mechanisms supported by TÜBİTAK 1001 programme and Unit of Uludag University Scientific Research Projects. Her doctoral studies were focused on the molecular relationship between the pyruvate dehydrogenase enzyme complex and epithelial mesenchymal transition in cancer cells. She obtained fundings from TUBITAK 1002 (as a project coordinator) programme and Unit of Uludag University Scientific Research Projects for her doctoral studies. In 2018, she is rewarded with the “MOKAD Young Basic Cancer Researcher” award by Molecular Cancer Research (MOKAD) and Basic Oncology Society. Dr. Cevatemre’s post doctoral research aims to explore the mechanisms of metabolism (Warburg effect), epithelial mesenchymal transition and tumor microenvironment-related resistance mechanisms in cancer cells.

Selected Publications

Icsel C, Yilmaz VT, Aygun M, Cevatemre B, Alper P, Ulukaya E. Palladium(ii) and platinum(ii) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells. Dalton Trans. 2018.

Cevatemre B, Erkısa M, Aztopal N, Karakas D, Alper P, Tsimplouli C, Sereti E, Dimas K, Armutak EII, Gurevin EG, Uvez A, Mori M, Berardozzi S, Ingallina C, D’Acquarica I, Botta B, Ozpolat B, Ulukaya E. A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer. Pharmacological Research. S1043-6618(17)30993-3. 2017.

Acilan C, Cevatemre B, Adiguzel Z, Karakas D, Ulukaya E, Ribeiro N, Correia I, Pessoa JC. Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents. BBA General Subjects. 1861(2):218-234. 2017.

Cevatemre B, Botta B, Mori M, Berardozzi S, Ingallina C, Ulukaya E. The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Chemico-Biological Interactions. 260:248-255. 2016.

Karakas D*, Cevatemre B*, Aztopal N, Ari F, Yilmaz VT, Ulukaya E. Addition of niclosamide to palladium(II) saccharinate complex of terpyridine results in enhanced cytotoxic activity inducing apoptosis on cancer stem cells of breast cancer. Bioorganic & Medicinal Chemistry. 23(17):5580-5586. 2015. Equal contribution*

Cevatemre B, Ulukaya E, Sarimahmut M, Oral A.Y, Frame F. The M30 Assay does not detect apoptosis in epithelial-derived cancer cells expressing low levels of cytokeratin 18. Tumor Biology. 36(9):6857-6865. 2015.

Ulukaya E, Frame F, Cevatemre B, Pellacani D, Walker H, Mann V, Simms M, Stower M, Yilmaz V, Maitland N. Differential Cytotoxic Activity of a Novel Palladium-Based Compound on Prostate Cell Lines, Primary Prostate Epithelial Cells and Prostate Stem Cells. PLoS One. 10;8(5):e64278. 2013.