Dr. Bruno Reversade and Dr. Hülya Kayserili have discovered how babies grow their limbs and lungs.
Starting for fetuses with tetra-amelia syndrome, an international group of clinicians and researchers lead by Prof. Hulya Kayserili and Prof. Bruno Reversade at KOC University have identified RSPO2 as the key gene for the formations of arms and legs. Humans and animals that lack RSPO2 cannot form limbs while animals that are devoid of its two receptors RNF43/ZNRF3 will form extra limbs. These results have direct implications in our understanding of cancer since the same genes RSPO2 and RNF43/ZNRF3 are regularly mutated in colorectal cancer patients. These findings published in Nature may also explain why certain species such as salamanders can regrow limbs after amputation. Please click for full text: https://www.nature.com/articles/s41586-018-0118-y
Biocompotable Quantum Funels for Neural Photostimulation
In this article, Dr. Sedat Nizamoğlu, Dr. Afsun Şahin ve Dr. Halil Kavaklı demonstrated that the bioelectrical current generated by quantum dot based thin film neural interfaces can be significantly enhanced by using a quantum funnel structure composed of indium-based rainbow quantum dots. The graded energy profile of the funnel facilitates an improved transportation of the photogenerated charges in the nanoscale, leading to effective optical modulation of the neural membrane. Moreover, the biocompatibility of the biointerfaces offers an opportunity for their potential use for in vivo applications. Please click for full text: https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.9b01697