Nurhan Özlü, PhD.

Faculty Co-Director

Phone: +90 (212) 338-1071

E-Mail: nozlu@ku.edu.tr

Seda Kızılel, PhD.

Faculty Co-Director

Phone: +90 (212) 338-1836

E-Mail: skizilel@ku.edu.tr

Welcome to Omics Laboratory.

In our center, mass spectrometry-based proteomic methods are used to analyze the proteins obtained from tissues, cells and body fluids in a wide scale. Comparative proteomic approaches can detect even minor differences between control and diseased conditions. It can be used to investigate the effects of drugs used in cancer and other disease treatment on cellular proteins. The comparison between the different conditions is done qualitatively and quantitatively at the protein and posttranslational modification levels. In addition to protein identification, characterization and post-translational modification analyzes, proteomic approaches to protein complexes and protein-protein interactions are analyzed in detail.

Instrumental Systems

  • Thermo Scientific nano Sıvı Kromatografisi (n-LC)
  • Thermo Scientific Q-Exactive Orbitrap Kütle Spektroskopisi analitik sistemi (MS/MS)

Proteomic Analysis Laboratory

In our laboratory, studies are carried out in order to understand the changes in cell and cell surface due to cell division. Significant changes occur during cell division in cell surface, as well as large changes in cell. Proteins located on the surface of the cell are of great importance in terms of the environment in which the cells are located and their interaction with each other. One of our studies examines the shifts in the cell division of a protein found on the cell surface and thought to have served in the adhesion of the cells, and the mechanism of these changes. We are also studying in our laboratory that the proteins involved in the cleavage of chromosomes during cell division and in the even distribution of dividing cells. Studies on the determination of amino acid sequences and modifications that play a role in the function of these proteins are being made. Finally, tests are being made on the effects of cell division of drugs developed to target these proteins.

  • Thermo Fisher Scientific Proteome Discoverer
  • Matrix Science Mascot
  • Maxquant
  • Scaffold
  • Protein Pilot